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. Author manuscript; available in PMC: 2010 Apr 16.
Published in final edited form as: Neuron. 2009 Apr 16;62(1):42–52. doi: 10.1016/j.neuron.2009.03.024

Figure 1. Study design schematic.

Figure 1

Patient groups were compared to HC1 subjects to determine syndromic atrophy patterns. From these maps, distinct seed ROIs were extracted (see Table S2) and used in functional (HC2) and structural (HC1) correlation analyses. These experiments determined the functional intrinsic connectivity networks (ICNs 1-5) and structural covariance networks (SCNs 1-5) associated with each of the five syndrome-related seeds. ICN and SCN maps were then compared to all five syndromic atrophy maps to derive GOF scores, yielding 50 total scores ((5 ICN maps×5 atrophy maps) + (5 SCN maps×5 atrophy maps)), which are summarized in Figure 5.