Table 1.
Characteristics of Bcl-2 Proteins
| Proteins | Chr. Location 1 | Splicing 2 | Activation 3 |
|---|---|---|---|
| Antiapoptotic | |||
| Bcl-2 | 18q21.3 | 2 | Ph |
| Bcl-w | 14q11.2 - q12 | n.r. | |
| Mcl-1 | 1q21 | 2 | |
| Bcl-xL | 20pter-p12.1 | 5 | Deph / Ph |
| Bfl-1 | 15q24.3 | 2 | |
| Proapoptotic | |||
| Bax | 19q13.3 - q13.4 | 8 | Deph / Ph / p53 |
| Bak | 6p21.3 | n.r. | Con |
| Bid | 22q11.2 | 4 | Cl / p53 |
| Bad | 11cen-q12.3 | n.r. | Deph |
| Nbk/Bik | 22q13.2-q13.3 | n.r. | Ph / p53 |
| Hrk | 12q24.21 | n.r. | |
| Bim | 2q12-q13 | 10 | Ph |
| Bmf | 15q14 | n.r. | Ph |
| Puma | 19q13.3 - q13.4 | 2 | p53 |
| Noxa | 18q21.32 | n.r. | p53 |
1
Chromosomal location of bcl-2 genes.
2
Reported numbers of alternative splice products. For several splice variants, there is no function so far identified, as for several splice variants of Bim and two splice variants of Bax. For several proteins the number of splice products has not been reported (n.r.).
3
Mechanisms for activation of Bcl-2 proteins: Ph, phosphorylation; Deph, dephosphorylation; Cl, cleavage; Con, conformational change; p53, transactivation by p53.