Table 4.
Pharmacogenetics of Azathioprine (AZA) in Rheumatoid Arthritis (RA)
| Gene Symbol | Polymorphism | Effect of Polymorphism | Pharmacogenetics | References |
|---|---|---|---|---|
| TPMT | TPMT*2 | Low to intermediate activity of TPMT | Hematological and gastrointestinal toxicity | [81] |
| G238C | Decreased methylation of AZA | |||
| TPMT*3A | Low to intermediate activity of TPMT | Hematological and gastrointestinal toxicity | [81] | |
| G460A, A719G | Decreased methylation of AZA | |||
| TPMT*3C | Low to intermediate activity of TPMT | Hematological and gastrointestinal toxicity | [81] | |
| A719G | Decreased methylation of AZA |
TPMT = thiopurine methyltransferase.