Table 4.

“New Microdeletion Syndromes” Associated with Mental Retardation¹

Deleted Region	Typical Clinical Features (Apart from Mental Retardation)	References
1q41q42	Seizures, dysmorphic features, midline defects (Fryns syndrome?)	[73]
2p15p16.1	Developmental delay, short stature, microcephaly	[74]
3q29	Speech delay, autistic traits, dysmorphic features	[75]
12q14	Osteopoikilosis, short stature	[76]
15q13.3	Epilepsy, facial and digital dysmorphisms	[77]
15q24	Growth retardation, microcephaly, digital abnormalities, hypospadia, loose connective tissue	[78]
16p11.2p12.2	Distinct facial features, heart defects, short stature	[79]
17q21.31	Characteristic facial dismorphisms, hypotonia	[80]
22q11.2	Learning and behavioral problems	[81]

¹all these syndromes were discovered by array-CGH-based approaches.