Table 2.
Microarray analysis of mRNA expression in WAT from retroperitoneal and epididymal depots of untreated male rats
| Epididymal WAT | Retroperitoneal WAT | Fold Δ | P Value | |
|---|---|---|---|---|
| Signal transduction | ||||
| Guanylate cyclase activator 2a | 19.29 | 24.19 | 1.3↑ | <0.05 |
| PLC δ1 | 297.2 | 258.3 | 1.2↓ | <0.05 |
| PKC γ | 16.76 | 14.78 | 1.1 | >0.05 |
| Regulators of signal transduction | ||||
| RGS4 | 407.9 | 255.2 | 1.6↓ | <0.05 |
| RGS7 | 212.3 | 684.2 | 3.3↑ | <0.05 |
| G protein-coupled receptors | ||||
| GHS-R | 34.3 | 37.45 | 1.1 | >0.05 |
| Calmodulin-R3 | 497.9 | 374.4 | 1.3↓ | <0.05 |
| CRH-R1 | 12.33 | 15.34 | 1.2↑ | <0.05 |
| Dopamine-R1a | 8.966 | 10.11 | 1.1↑ | <0.05 |
| Secretin-R | 27.62 | 59.69 | 2.2↑ | <0.05 |
| GPR88 | 105.1 | 37.26 | 2.8↓ | <0.05 |
| SST-R5 | 15.46 | 18.16 | 1.2↑ | <0.05 |
| VPAC2 | 712.7 | 127.4 | 5.6↓ | <0.05 |
| Adipogenic | ||||
| PPARγ2 | 1,655 | 2,460 | 1.5 | >0.05 |
| Lipid regulators | ||||
| GLUT4 | 1,298 | 2,410 | 1.9↑ | <0.05 |
| Lipoprotein lipase | 12,929 | 10,556 | 1.2 | >0.05 |
| CD36 | 676.5 | 465.1 | 1.5 | >0.05 |
| Fatty acid synthase | 8,886 | 12,475 | 1.4↑ | <0.05 |
| Perilipin | 321.5 | 310.8 | 1.0 | >0.05 |
| LXRα | 591.9 | 631.0 | 1.1 | >0.05 |
| UCP1 | 15.24 | 166.7 | 11 | >0.05 |
| Lipolytic | ||||
| Hormone-sensitive lipase | 3,599 | 3,258 | 1.1 | >0.05 |
| ABCG1 | 83.93 | 83.91 | 1.0 | >0.05 |
| STAR | 125 | 1,317 | 11↑ | <0.05 |
Values shown are means of raw data obtained from samples from four different rats, with statistical comparisons performed by Student’s t test and Benjamini and Hochberg False Discovery Rate test.
PLC, Phospholipase C; PKC, protein kinase C; RGS, regulator of G protein signaling; CRH-R, CRH receptor; SST-R, somatostatin receptor; VPAC, vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor; UCP, uncoupling protein; STAR, steroidogenic acute regulatory protein.
↑, Higher in retroperitoneal adipose tissue.
↓, Higher in epididymal adipose tissue.