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. 2009 Apr 27;3:42. doi: 10.1186/1752-0509-3-42

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Copyright © 2009 Li et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Schematic representations of VPC fate specification in wild-type hermaphrodites. (a) The anchor cell produces a graded inductive signal and causes six equivalent cells to adopt fates in a precise pattern. (b) The sublineage is generated according to each specified cell fate. The sublineage is a determined pattern of cell divisions which produces a characteristic set of progeny cell types. Sternberg and Horvitz have defined vulval cell types (after two rounds of VPC divisions) by two criteria as follows: the axis of the third round nuclear divisions (L, longitudinal axis; T, transverse axis; N, no division; S is to join the large hypodermal syncytium (hyp7)), and adherence to the ventral cuticle [32].