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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: J Vasc Surg. 2009 May;49(5):1296–1303. doi: 10.1016/j.jvs.2008.12.026

Figure 4.

Figure 4

EGFR phosphorylation by ATF (10nM) was inhibited by pre-incubation with heparin (100U/ml), blockade of the ligand HB-EGF with the HB-EGF inhibitor CRM197 and an Anti-HB-EGF antibody. IgG had no effect. EGF-mediated activation of EGFR was not blocked by these inhibitors. Direct blockade of the EGFR prevented activation by both ATF and EGF. Values are the mean±SEM of the ratio of the phosphorylation of EGFR relative to the total unphosphosphorylated EGFR (n=6, **p<0.01 compared to control). Representative Western blots are shown above the graphs.