Figure 2.

Gene expression results for a set of 94 messenger RNAs (mRNAs) evaluated by multiplex reverse transcription–polymerase chain reaction in groups of seven to nine mice. The horizontal axis reports the ratio of expression in liver of methionine-restricted (Meth-R) compared with Meth-C mice. The vertical axis shows the ratio of expression in liver of caloric restriction (CR) compared with ad libitum (AL) control mice. Filled symbols show genes for which a test of false discovery rate showed p < .05 for the comparison of CR with AL mice. Underlined gene names show the three mRNA for which the false discovery statistic reached p < .05 for the comparison between Meth-R and Meth-C mice. Gene names are given for 11 arbitrarily selected genes; a complete listing is included in Supplementary Table 1.