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Three distinct sub-motifs of the CRP binding sites correspond to three top-ranked clusters. The all known CRP binding sites (A), can be subdivided into a more information-rich canonical palindromic sub-motif (B), a T-rich motif (C) and an A-rich sub-motif (D). Our predicted eighth (E), 72-th (F) and 178-th (G) clusters, largely correspond to the CRP's canonical palindromic sub-motif (B), the T-rich motif (C) and the A-rich sub-motif (D), respectively.
