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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2008 Oct 10;1789(4):315–325. doi: 10.1016/j.bbagrm.2008.09.006

Figure 2.

Figure 2

Model for the SHR-SCR pathway. SHR is expressed in the stele and the protein moves into the endodermis, QC, and CEI, where it activates expression of SCR. SCR induces an asymmetric periclinal division in the CEI daughter that results in one layer of endodermis and one of cortex. In the endodermis and CEI, SCR autoinduces and interacts with SHR to sequester it in the nucleus, preventing SHR movement and the production of supernumary layers. SCR and SHR must be quickly degraded in the cortex by unknown factors. JKD may act directly with SHR or indirectly through SCR to restrict SHR movement. MGP is epistatic to JKD, and though the mechanism has yet to be determined, it may counteract the effect of JKD by interfering with a JKD-SCR-SHR complex. WOX5 acts non-autonomously to suppress columella stem cell differentiation and redundantly with other factors to suppress differentiation of the other initials. See text for additional details.