Table 3.

Response of piperaquine resistant Plasmodium berghei GFP ANKA line to amodiaquine (AQ), chloroquine (CQ), lumefantrine (LM) and dihydroartemisinin (DHA). Results are presented as effective doses that reduce parasitaemia by 90% (ED₉₀) and as 90% indexes of resistance (I₉₀, defined as the ratio of the ED₉₀ of the resistant line to that of the sensitive, parent strain).

Antimalarial drug	ED90⁎ (mg/kg)		Index of resistance (I90)
	Parent strain	Resistant line
AQ	3.72	13.48§	3.62
LM	2.52	245.06¶	97.25
CQ	3.57	26.24‡	7.35
DHA	4.08	12.06§	2.96

^⁎Differences between parent and resistant lines were significant according to Student’s t-test.

^‡p < 0.01.

^§p < 0.001.

^¶p < 0.0001.