Table 4.

Response of lumefantrine resistant Plasmodium berghei GFP-Luciferase ANKA line to amodiaquine (AQ), piperaquine (PQ), chloroquine (CQ) and dihydroartemisinin (DHA). Results are presented as effective doses that reduce parasitaemia by 90% (ED₉₀) and as 90% indexes of resistance (I₉₀, defined as the ratio of the ED₉₀ of the resistant line to that of the sensitive, parent strain).

Antimalarial drug	ED90⁎(mg/kg)		Index of resistance (I90)
	Parent strain	Resistant line
AQ	4.29	4.53†	1.06
PQ	3.70	3.37†	0.91
CQ	4.47	7.22¶	1.62
DHA	6.69	35.86‡	5.36

^⁎Differences between parent and resistant lines were analyzed by Student’s t-test.

^†p > 0.05 (insignificant).

^‡Significant at p < 0.05.

^¶Significant at p < 0.0001.