Figure 1:

Binding pockets in threading templates: glutathione S-transferase (GST) from R. norvegicus (PDB-ID: 1b4p), Z. mays (PDB-ID: 1bye) and H. sapiens (PDB-ID: 17gs) upon the global superposition onto the target structure, GST from E. coli (PDB-ID: 1a0f, not shown). Template-bound ligands are presented as black sticks. Selected binding residues are shown as gray sticks and labeled by the equivalent positions in the target sequence. The sequence identity to the target as well as the pairwise sequence identities between the templates is in the range of 15–25%.