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. 2009 Jun 16;4(6):e5930. doi: 10.1371/journal.pone.0005930

Figure 4. Protective efficacy of different doses of Ag85B-TB10.4 in IC31®.

Figure 4

In two independent experiments (A and B) groups of mice were vaccinated with three different doses of H4 formulated in IC31® and compared to saline and BCG vaccinated controls. All groups were challenged by the aerosol route with virulent M.tb ten weeks after the first vaccination. Six weeks post-challenge, all mice were killed and the bacterial burden (CFU) was measured in the lung. In both experiments data are presented as mean values from six animals per group and standard errors of the means are indicated by bars. Statistical comparison among the vaccination groups were done by one-way ANOVA and Tukey's post test. Significant differences are shown. ***: p<0.001, *: p<0.05.