Fig. 3.

Regulatory T cell (T_reg) proportions (as a percentage of CD4 lymphocytes) stratified by clinical characteristics. (a) Common variable immunodeficiency (CVID) patients with (CVID + CI) or without (CVID − CI) chronic infections (CI), as defined in the legend to Table 1; (b) CVID patients with (CVID + gran) or without (CVID − gran) granulomata (gran); (c,d) CVID patients with (CVID + LPD) or without (CVID − LPD) lymphoproliferative disease (LPD), including lymphadenopathy or splenomegaly. (e,f) CVID patients with (CVID + AID) or without (CVID − AID) autoimmune disease, T_reg cell proportions in European patients defined by the phenotype CD25⁺/forkhead box P3 (FoxP3)⁺ (e), or CD25⁺/CD127^low T_reg cells from the Sydney cohort (f). (g,h) CVID patients with (CVID + AICP) or without (CVID − AICP) autoimmune cytopenias at any stage in the course of their disease, T_reg cell proportions in European patients defined by the phenotype CD25⁺/FoxP3⁺ (g), or CD25⁺/CD127^low T_reg cells from the Sydney cohort (h). (a–c,e,g) T_reg cell proportions in European patients defined by the phenotype CD25⁺/FoxP3⁺; (d,f,h) CD25⁺/CD127^low T_reg cells from the Sydney cohort.