Table 2.
Primary and secondary outcomes
| Thigh-length GCS (n=1256) | Avoid GCS (n=1262) | Odds ratio (95% CI) | |
|---|---|---|---|
| Primary outcome | |||
| Proximal DVT | 126 (10·0%) | 133 (10·5%) | .. |
| Alive and free of primary outcome | 974 (77·5%) | 1000 (79·2%) | .. |
| Dead before any primary outcome | 115 (9·2%) | 101 (8·0%) | .. |
| Missing | 41 (3·3%) | 28 (2·2%) | .. |
| Unadjusted (dead and missing excluded) | .. | .. | 0·97 (0·75-1·26) |
| Adjusted* (dead and missing excluded) | .. | .. | 0·98 (0·76-1·27) |
| Secondary outcomes by 30 days or later second compression Doppler ultrasound | |||
| Dead by 30 days | 122 (9·7%) | 110 (8·7%) | 1·13 (0·86–1·48) |
| Symptomatic proximal DVT | 36 (2·9%) | 43 (3·4%) | 0·84 (0·53–1·31) |
| Asymptomatic proximal DVT | 90 (7·2%) | 90 (7·1%) | 1·01 (0·74–1·36) |
| Symptomatic DVT (proximal or distal) | 55 (4·4%) | 61 (4·8%) | 0·90 (0·62–1·31) |
| Any DVT (proximal or distal) | 205 (16·3%) | 224 (17·7%) | 0·90 (0·73–1·11) |
| PE confirmed on imaging or autopsy | 13 (1·0%) | 20 (1·6%) | 0·65 (0·32–1·31) |
| PE on autopsy | 1 (0·1%) | 1 (0·1%) | 1·00 (0·06–16·08) |
| Any DVT or PE | 213 (17·0%) | 232 (18·4%) | 0·91 (0·74–1·11) |
| Skin breaks/ulcers/blisters/skin necrosis | 64 (5·1%) | 16 (1·3%) | 4·18 (2·40–7·27) |
| Lower limb ischaemia/amputation | 7 (0·6%) | 2 (0·2%) | 3·53 (0·73–17·03) |
| Primary outcomes within 14 days | |||
| Post-hoc analysis restricting follow-up to 14 days† | 87 (6·9%) | 95 (7·5%) | .. |
| Unadjusted (dead and missing excluded) | .. | .. | 0·95 (0·70–1·28) |
| Adjusted* (dead and missing excluded) | .. | .. | 0·95 (0·70–1·29) |
Data are number (%) unless otherwise indicated. GCS=graduated compression stockings. DVT=deep vein thrombosis. PE=pulmonary embolism.
*
Adjusted for delay from onset to randomisation, stroke severity, and leg strength at baseline.
†
Full compliance by 14 days was 79·4% compared with 73·1% by 30 days.