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. Author manuscript; available in PMC: 2009 Oct 9.
Published in final edited form as: Nature. 2009 Mar 11;458(7239):725–731. doi: 10.1038/nature07782

Figure 5. A K-RAS mouse model of lung cancer but not a PTEN-null model of prostate cancer is sensitive to DR.

Figure 5

a, Representative images of lungs and average diameter of tumour nodules on the surface of the lungs (graph) of 7-week-old K-RASLA2; P53 LSL/ WT mice under AL or DR conditions (n=3). b-d, H&E staining (b) and immunohistochemical analyses of Ki-67 (c) and cleaved caspase-3 (d) in sections prepared from lungs in a. e-h, H&E staining (e) and immunohistochemical analyses of phospho-Akt S473 (f), Ki-67 (g), and cleaved caspase-3 (h) in prostates of 11-week-old Probasin-Cre; PTEN L/L mice under AL or DR conditions. In c, d, g, and h, graphs to right of respective images indicate percent of total cells that are positive for Ki-67 or cleaved caspase-3. Graphs show means ± s.e.m. of percent of proliferating (c and g) or apoptotic cells (d and h) measured in 10 images (1000 nuclei counted per image) from 2 different tumours per group. All pictures were captured under the same magnification and scale bar = 20 µm. ** indicates P = 8.3 × 10−8.