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. Author manuscript; available in PMC: 2010 May 6.
Published in final edited form as: J Am Chem Soc. 2009 May 6;131(17):6093–6095. doi: 10.1021/ja900450h

Figure 1.

Figure 1

Transition-state scheme and activity profiles for adenosine and N1-deazaadenosine. (A) Transition-state stabilization of small ribozymes. (B) Single turnover cleavage of adenosine and N1dA at position 38 of the hairpin ribozyme crystallization construct (Figure S1). The kobs for wild type was 0.7 ± 0.2 min-1. The reaction was monitored for 50 hr and showed no evidence of cleavage. (inset) Bases at position 38 of this