Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Distinct end cleaning activities of various enzymes. APE1 removes 3′ blocking PUA (boxed in red in A) while PNK removes 3′ phosphate (boxed in red in B). Polβ removes 5′ blocking dRP (boxed in red in C). Aprataxin hydrolyzes 5′-5′ linkage of AMP to the 5′ phosphate (D). The dRP lyase activity Polβ requires the aldehyde group.
