. Author manuscript; available in PMC: 2009 Jun 8.

Published in final edited form as: Cell Res. 2008 Jan;18(1):27–47. doi: 10.1038/cr.2008.8

Table 1.

Mammalian DNA glycosylases and their prototypes in E. coli

Enzyme	E. coli			Human
		Type	Preferred substrate		Type	Preferred substrate
Uracil DNA glycosylase (UDGs)	Ung	Monofunctional	uracil	UNG SMUG1 TDG	Monofunctional Monofunctional Monofunctional	uracil uracil U and T in U(T) •G
Alkylbase DNA glycosylase	Tag AlkA	Monofunctional	3-methyladenine	MPG	Monofunctional	3-methyladenine, hypoxanthine
Adenine-specific mismatch DNA glycosylase	MutY	Monofunctional	A in 8-oxoG•A	MYH	Monofunctional	A in 8-oxoG•A
DNA glycosylases for oxidized bases	EndoIII (Nth)	Bifunctional (β lyase)	5-OHC, 5-OHU, Tg	NTH1 OGG1	Bifunctional (β) Bifunctional (β)	Tg, 5-formylU, 8-oxoG, Fapy-G
DNA glycosylases for oxidized bases	EndoVIII (Nei) Fpg (MutM)	Bifunctional (βδ lyase)	Tg, 5-OHU 8-oxoG Fapy-G (−A)	NEIL1 NEIL2	Bifunctional (βδ) Bifunctional (βδ)	Fapy-A (−G), Tg, 5-OHU Hydantoin (Sp, Gu), 5-OHU

SP, spiriminohydantoin; Gu, guanidinohydantoin; Tg, thymine glycol; Fapy, formamidopyrimidine