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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: J Leukoc Biol. 2008 Jan 22;83(5):1079–1087. doi: 10.1189/jlb.1107725

Figure 3. (A) Isolated human eosinophils and (B) recombinant, ribonucleolytically active EDN reduce the infectivity of the pathogen, respiratory syncytial virus (RSV) for target epithelial cells in vitro.

Figure 3

As shown, ribonucleolytically inactivated EDN (catalytic lysine K38 converted to arginine) has no antiviral activity, although the mechanism via which EDN reduces virus infectivity remains otherwise unclear. Reprinted with permission from Domachowske et al. [4].