Table 3.
Adjusteda regression coefficients (95% confidence intervals) for change in hormone levels associated with SG-adjusted pyrethroid metabolite groups. N=161.
| Metabolite Percentiles | Adjusted Regression Coefficients (95% CI) |
|||||
|---|---|---|---|---|---|---|
| FSHb | LHb | Inhibin Bc | Testosteroned | SHBGb | FAIb | |
| 3PBA | ||||||
| <50th | 0 | 0 | 0 | 0 | 0 | 0 |
| 50th–75th | 0.05 (−0.17, 0.28) | −0.05 (−0.25, 0.15) | −3.46 (−32.6, 25.7) | 6.31 (−34.9, 47.5) | 0.02 (−0.13, 0.16) | 0.02 (−0.12, 0.15) |
| >75th | 0.38 (0.15, 0.60) | 0.20 (−0.004, 0.41) | −18.2 (−47.8, 11.4) | −27.4 (−68.3, 14.6) | 0.08 (−0.07, 0.23) | −0.13 (−0.27, 0.02) |
| p for trend | 0.002 | 0.10 | 0.25 | 0.27 | 0.30 | 0.12 |
|
| ||||||
| cis-DCCA | ||||||
| <50th | 0 | 0 | 0 | 0 | 0 | 0 |
| 50th–75th | 0.21 (−0.03, 0.44) | 0.32 (0.12, 0.53) | −15.2 (−45.2, 14.8) | −6.67 (−49.7, 36.4) | 0.05 (−0.10, 0.20) | −0.04 (−0.19, 0.10) |
| >75th | 0.26 (0.02, 0.49) | 0.22 (0.02, 0.43) | −32.0 (−61.8, −2.16) | −8.86 (−51.5, 33.8) | −0.03 (−0.18, 0.12) | 0.002 (−0.14, 0.15) |
| p for trend | 0.02 | 0.01 | 0.03 | 0.66 | 0.77 | 0.94 |
|
| ||||||
| trans-DCCA | ||||||
| <50th | 0 | 0 | 0 | 0 | 0 | 0 |
| 50th–75th | 0.08 (−0.14, 0.31) | 0.05 (−0.15, 0.26) | −7.37 (−36.6, 21.8) | −7.84 (−49.1, 33.5) | −0.02 (−0.17, 0.13) | 0.01 (−0.13, 0.14) |
| >75th | 0.28 (0.05, 0.51) | 0.20 (−0.004, 0.41) | −34.8 (−64.0, −5.64) | −37.7 (−79.7, 4.29) | 0.08 (−0.07, 0.23) | −0.15 (−0.29, −0.01) |
| p for trend | 0.02 | 0.06 | 0.02 | 0.09* | 0.34 | 0.05 |
|
| ||||||
| cis- + trans-DCCA | ||||||
| <50th | 0 | 0 | 0 | 0 | 0 | 0 |
| 50th–75th | 0.09 (−0.14, 0.31) | 0.05 (−0.15, 0.26) | 0.43 (−28.6, 29.4) | −9.37 (−51.1, 32.3) | 0.04 (−0.10, 0.19) | −0.03 (−0.17, 0.11) |
| >75th | 0.29 (0.06, 0.52) | 0.24 (0.03, 0.44) | −31.1 (−60.4, −1.70) | −26.9 (−68.9, 15.2) | 0.04 (−0.11, 0.19) | −0.10 (−0.24, 0.04) |
| p for trend | 0.03 | 0.03 | 0.06 | 0.21 | 0.57 | 0.16 |
|
| ||||||
| Sum Pyrethroids | ||||||
| <50th | 0 | 0 | 0 | 0 | 0 | 0 |
| 50th–75th | 0.04 (−0.19, 0.26) | 0.06 (−0.15 (0.26) | −8.70 (−37.8, 20.4) | −35.5 (−76.5, 5.56) | 0.05 (−0.09, 0.20) | −0.09 (−0.22, 0.05) |
| >75th | 0.32 (0.10, 0.55) | 0.19 (−0.02, 0.39) | −23.7 (−53.3, 5.86) | −41.4 (−83.1, 0.36) | 0.09 (−0.06, 0.24) | −0.16 (−0.30, −0.02) |
| p for trend | 0.009 | 0.08 | 0.12 | 0.03 | 0.21 | 0.02 |
a
Adjusted for age, BMI, smoking and time of day at blood draw. N=161.
b
Variable transformed by the natural logarithm.
c
additionally adjusted for season.
d
additionally adjusted for ln-transformed SHBG.
*
statistically significant trend in unadjusted (crude) model (p-value for trend < 0.05).