Table 1.

Analysis of mutations of HTNV vRNA in the presence or absence of ETAR

				Placebo-treated	ETAR 10 μg/mL
Analyzed nucleotides				111,510	111,510
No. of cDNAs examined				90	90
Mutated nucleotides				19	17
Average mutation frequency (per 10,000)				1.7	1.5
% of cDNAs with mutations				17.8%	17.8%
% of C→U or G→A in total mutation				42.1%	29.4%
C→T mutations per 10,000 nt				0.4	0.2
G→A mutations per 10,000 nt				0.4	0.3
Mutation type	Point	Transition		11	9
		Transversion		5	7
		Amino acid change	Missense	9	9
			Nonsense	0	1
			Silent	3	5
	Frame shift			3	1