Figure 5.

Blocking of the protective effect of resistin by an inhibitor of PKC, chelerythrine (CHE; Panel A) or PKCε, εV1-2 (Panel B). Mice were injected with CHE (5 mg/kg, i.p.), εV1-2 (0.2 mg/kg, i.p) or Tat carrier (83 μg/kg, i.p.) 15 min before the administration of resistin (3.3 μg/kg). After 15 min, mice were subjected to LAD ligation followed by 4 h of reperfusion. n=6, a=P<0.05 vs. Control. Control and resistin treated data are the same as that shown in Figure 3.