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Immunohistochemical analysis of mouse ER-α expression in lung adenocarcinoma in adult female mice induced by in utero arsenic exposure. (A) Morphology of arsenic-induced lung adenocarcinoma (hematoxylin and eosin, ×400). (B) Immunohistochemical analysis for ER-α expression in a typical arsenic-induced lung adenocarcinoma (×400). The lung adenocarcinoma shows widespread and intense expression for ER-α (brown staining), particularly in the tumor cell nuclei.
