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Immunohistochemical analysis of ER-α expression of mouse lung tumors induced by in utero arsenic exposure or DEN treatment in adulthood. (A) ER-α expression in a typical lung adenoma (×100) induced by in utero arsenic exposure showing widespread and intense expression for ER-α (brown staining), particularly in the tumor cell nuclei. (B) ER-α expression in a DEN-induced lung adenocarcinoma (×100) showing little or no expression.
