Table 1.
Minocycline protects motor but not autonomic neurons after VRA injury. PPNs and motoneurons were identified by ChAT immunoreactivity. Non-lesioned and avulsed sides of the lumbosacral spinal cord were compared in 10 sections per animal.
| Total # of PPNs | Total # of MNs | |||
|---|---|---|---|---|
| Vehicle | Non-lesioned | Avulsed | Non-lesioned | Avulsed |
| Rat #1 | 75 | 36 | 44 | 3 |
| Rat #2 | 54 | 22 | 51 | 10 |
| Rat #3 | 96 | 44 | 51 | 9 |
| Rat #4 | 67 | 44 | 57 | 14 |
| Rat #5 | 133 | 27 | 70 | 11 |
| Rat #6 | 83 | 58 | 60 | 7 |
| Minocycline | ||||
| Rat #1 | 94 | 29 | 48 | 7 |
| Rat #2 | 79 | 19 | 49 | 14 |
| Rat #3 | 90 | 52 | 47 | 17 |
| Rat #4 | 105 | 48 | 61 | 7 |
| Rat #5 | 102 | 54 | 50 | 24 |
| Rat #6 | 108 | 65 | 68 | 39 |
| Rat #7 | 102 | 46 | 58 | 20 |