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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Breast Cancer Res Treat. 2008 Apr 25;114(3):549–558. doi: 10.1007/s10549-008-0026-1

Table 5.

Age adjusted hazard ratios (HR) and 95% confidence intervals (CI) of breast cancer tumor subtype associated with the degree of affected relatives1

Luminal A2 Luminal B3 HER2-neu Over-expressing4 Basal5
Relative with breast cancer N HR6 (95%CI) N HR6 (95%CI) N HR6 (95%CI) N HR6 (95%CI)
No family history (Ref.) 191 1.0 11 1.0 5 1.0 36 1.0
2nd degree history only 75 1.23 (0.94-1.61) 8 1.98 (0.79-4.94) 9 4.87 (1.62-14.6) 4 0.33 (0.12-0.93)
Any 1st degree history 125 1.78 (1.42-2.23) 8 2.10 (0.84-5.22) 5 2.91 (0.84-10.1) 13 1.01 (0.53-1.90)
1

Estimated using Cox Proportional Hazards models among women in the Group Health Breast Cancer Screening Program between June 1, 2001 and December 31, 2005

2

ER+ and/or PR+, HER2-

3

ER+ and/or PR+, HER2+

4

ER-, PR-, HER2+

5

ER-, PR-, HER2-

6

Adjusted for age at baseline (quadratic)