Figure 4.
Functionality of nanoparticle-labeled CTLs. Flow cytometry analysis of the functionality of CTLs incubated with control/targeting nanoparticles (left) and control nanoparticles/tetramer (right) 18 hrs post incubation. Cells incubated with nanoparticles or tetramers were probed for upregulation of CD69, an early indicator of T cell activation. Targeting nanoparticles demonstrated T cell functionality comparable to MHC- peptide tetramers after loading.