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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2009 Feb 21;1790(6):445–455. doi: 10.1016/j.bbagen.2009.02.009

Figure 4. Model for establishment of transcriptional memory through chromatin remodeling by SWI/SNF.

Figure 4

Intracellular galactose activates the Gal4p activator, which recruits RNA Polymerase II and other components of the transcriptional machinery. This leads to transcription of GAL1, GAL7 and GAL10 genes. Transcription leads to formation of memory, which can be inhibited by ISWI complexes. Activated Gal4p also recruits SWI/SNF, which antagonizes the repressive function of ISWI complexes at these loci, thereby contributing to establishment of transcriptional memory.