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. Author manuscript; available in PMC: 2010 Feb 5.
Published in final edited form as: Mol Cell Endocrinol. 2008 Nov 21;299(1):32–38. doi: 10.1016/j.mce.2008.11.012

FIG. 4.

FIG. 4

The steroid-induced LH is blunted and delayed in rats that were treated with antisense oligos to VIP or control scrambled oligos directly at the suprachiasmatic nucleus (SCN). Ovariectomized, estradiol-treated young rats were administered antisense or scrambled oligos and sequentially bled. The steroid-induced surge of LH exhibited changes that are remarkably like those observed during aging. [Reprinted with permission from Harney JP, Scarbrough K, Rosewell KL, Wise PM 1996 In vivo antisense antagonism of vasoactive intestinal peptide in the suprachiasmatic nucleus causes aging-like changes in the estradiol-induced LH and prolactin surge. Endocrinology 137:3696–3701. Copyright The Endocrine Society.]