Fig. 1.

Schematic representation of connexin46 (Cx46) and Cx46 mutants. The diagram (extracellular-surface up) shows the location of Cys residues, denoted by circles. Cx46, wild-type rat Cx46; Cx46-C3A, Cx46 with intracellular and M4 Cys mutated to Ala; Cx46ΔCT, Cx46 with truncation of the COOH-terminal domain at position 239; Cx46-CT43, chimera in which the Cx43 COOH terminus (thicker line) was fused to Cx46ΔCT. In addition to Cys218, it has 3 additional cysteines at positions 256, 267, and 294.