Fig. 4.
GSNO alters Cx46 and Cx46-CT43 hemichannel tail currents. A–D: typical tail-current records from Xenopus oocytes expressing wild-type Cx46 and Cx46 mutants, before and after exposure to GSNO (after NO). See Fig. 2 for details. E: effect of NO on peak tail-current amplitudes elicited upon transition from +60 mV to −60 mV. Bars are means ± SE of 11 (Cx46), 10 (Cx46-C3A), 4 (Cx46ΔCT), and 9 (Cx46-CT43) experiments. **P < 0.01 and ***P < 0.001. The dotted line denotes control values. F: effects of NO on tail-current kinetics. The data were fit to a two-exponential equation, and the resulting time constants, fast (τfast) and slow (τslow), are shown as means ± SE of the NO values relative to control. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with control.