Fig. 10.
Chronic effect of TGF-α on a single channel is blocked by U0126, a MEK inhibitor. A: current traces from cell-attached patches from untreated cells and cells treated with TGF-α (20 ng/ml), TGF-α+U0126 (10 μM), and U0126 alone. The patches were held at +40 mV, with inward current downward. Closed and open states are denoted by C and O, respectively. B: summary of number of ENaC per patch in all conditions. *P < 0.05 vs. Con. #P < 0.05 vs. TGF-α+U0126. C: summary of ENaC Po in all conditions.