Fig. 13.
Acute treatment with TGF-α (20 ng/ml) or EGF (100 ng/ml) increases the Po of the channel and does not change the number of ENaC per patch. A: current traces from cell-attached patches from control and TGF-α (20 ng/ml)-treated cells (30 min to 2 h). The patches were held at +40 mV with inward current downward. Closed and open states are denoted by C and O, respectively. B: summary of ENaC Po in control and TGF-α groups. C: summary of the number of ENaC per patch in control and TGF-α groups. *P < 0.05 vs. Con.