Fig. 2.
Chronic treatment with TGF-α (20 ng/ml) or EGF (100 ng/ml) reduces the number of epithelial Na channels (ENaC) per patch, but not the open probability (Po) of the channels. A: current traces from cell-attached patches from control and TGF-α (20 ng/ml)-treated cells. The patches were held at +40 mV, with inward current downward. Closed and open states are denoted by C and O, respectively. B: summary of number of channels per patch in control and TGF-α groups. *P < 0.05 vs. Con. C: summary of ENaC Po in control and TGF-α groups.