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Chronic effect of TGF-α is blocked by the EGFR inhibitor AG1478. A: current traces from cell-attached patches from untreated cells and cells treated with TGF-α (20 ng/ml), TGF-α+AG1478 (5 μM), and AG1478 alone. The patches were held at +40 mV, with inward current downward. Closed and open states are denoted by C and O, respectively. B. summary of number of ENaC per patch in 4 conditions. *P < 0.05 vs. Con. #P < 0.05 vs. TGF-α+AG1478.
