Table I.
Protein translation-related proteins identified in the aggresome-enriched fraction of HEK293 cells exposed to Cd2+. Proteomic data of the DB-insoluble fraction of HEK293 cells cultured in the presence or absence of Cd2+ were compared. Listed here are the components of protein translation machinery. The ratio of identified peptides for each protein (Agg/Ctrl) between the Cd2+-treated sample (Agg _peptides) and the control (Ctrl_peptides) was calculated.
| Protein | Agg_peptides | Ctrl_peptides | Agg/Ctrl | Reference |
|---|---|---|---|---|
| Seryl-tRNA synthetase (EC 6.1.1.11) | 28 | 0 | / | SYS_HUMAN |
| Tryptophanyl-tRNA synthetase (EC 6.1.1.2) | 25 | 1 | 25 | SYW_HUMAN |
| Asparaginyl-tRNA synthetase, cytoplasmic (EC 6.1.1.22) | 40 | 2 | 20 | SYNC_HUMAN |
| Alanyl-tRNA synthetase (EC 6.1.1.7) | 93 | 5 | 19 | SYA_HUMAN |
| Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1) | 49 | 3 | 16 | SYYC_HUMAN |
| Eukaryotic translation initiation factor 3 subunit 6 (eIF-3 p48) (eIF3e) | 56 | 0 | / | IF36_HUMAN |
| Translation initiation factor eIF-2B delta subunit | 16 | 0 | / | EI2BD_HUMAN |
| Eukaryotic translation initiation factor 3 subunit 5 (eIF3f) | 20 | 1 | 20 | IF35_HUMAN |
| Eukaryotic translation initiation factor 5A (eIF-5A) | 135 | 7 | 19 | IF5A_HUMAN |
| 40S ribosomal protein S10 | 33 | 2 | 17 | RS10_HUMAN |
| 60S ribosomal protein L26 | 15 | 1 | 15 | RL26_HUMAN |