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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Biochem J. 2008 May 1;411(3):523–530. doi: 10.1042/BJ20071436

Figure 7. Alignment of Top1 junction region amino acid sequences.

Figure 7

Indicated nuclear Top1s with junction region aa shown in single letter code. The conserved WXWW motif that forms the Trp anchor in human Top1 is in bold and underlined. *Yeast (Saccharomyces cerevisiae) contains a Tyr in place of human Top1 Trp203, and a Lys in place of human Top1 Glu208, both are in bold. Plant and bacterial Top1s lack a WXWW motif and so are not shown (see Results and Discussion).