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Wild-type and mutant Trp anchor interaction energy scores
| Energy: | Total | Van der Waals | Electrostatic |
|---|---|---|---|
| Top1 wild-type | -94.05* | -72.10 | -21.95 |
| Top1 W203A | -85.00 | -62.70 | -22.30 |
| Top1 W205A | -79.73 | -58.65 | -21.08 |
| Top1 W206A | -81.82 | -62.43 | -19.39 |
| Top168W/A** | -58.16 | -39.59 | -18.57 |
Interaction energy scores between aa 201-214 of wild-type and W/A mutant Top1s and Top1 aa 215-765 and bound DNA.
All values are in Kcal/mol.
Top68W/A, 203/205/206 W/A triple mutant.
