Table 3.
Ratio of 6 mg/kg:4 mg/kg daptomycin (95% CI) |
||
---|---|---|
day 1 | day 7 | |
AUC0–tau (dose-normalized) | 1.02 (0.87–1.2) | 0.99 (0.87–1.12) |
CL | 1.00 (0.85–1.18) | 1.01 (0.9–1.15) |
Cmax (dose-normalized) | 1.14 (0.97–1.3) | 0.97 (0.82–1.16) |
Ae0–tau (dose-normalized) | 0.95 (0.72–1.25) | 0.88 (0.69–1.11) |
Ae0–tau, cumulative amount of unchanged daptomycin excreted in urine; AUC0–tau, area under the plasma concentration–time curve over the dosing period.