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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: J Neurochem. 2009 Jan 23;109(1):116–124. doi: 10.1111/j.1471-4159.2009.05921.x

Figure 6. Protection of mouse cortical neurons from NMDA-induced injury by mouse and human 3K3A-APC.

Figure 6

(A) Dose-dependent neuroprotection by mouse and CHO-derived human 3K3A-APC at 24 h of NMDA. Cell survival was quantified with WST-8 assay. (B) IC50 values for mouse and human 3K3A-APC from dose-response curves shown in Fig. 6A. Values are mean ± SEM, n=3-5 independent experiments in triplicate. NMDA label at zero concentration APC on the abscissa shows cell survival of neurons treated with NMDA only without 3K3A-APC. Vehicle denotes the basal cell survival rate of neurons in the culture medium in the absence of NMDA.