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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Virus Res. 2008 Sep 20;139(2):240–252. doi: 10.1016/j.virusres.2008.07.027

Figure 4. VPg and cis-active RNA sequences and structures required for poliovirus RNA replication.

Figure 4

VPg, a 22 amino acid long viral protein, is covalently linked by the tyrosine hydroxyl to the 5′ terminus of viral RNA via a phosphodiester (Ambros and Baltimore, 1978). There are four distinct cis-active RNA sequences and structures required for RNA replication: a cloverleaf RNA sequence and structure at the 5′ terminus (5′ CL), a cis-replication element (CRE) in the open reading frame, a 3′ nontranslated region (3′ NTR), and a 3′ poly(A) tail.