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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Virus Res. 2008 Sep 20;139(2):240–252. doi: 10.1016/j.virusres.2008.07.027

Figure 7. CRE-dependent VPgpUpUOH synthesis and translocation to the 3′ termini of viral RNA templates for RNA replication.

Figure 7

3DPol and VPgpUpUOH must translocate from the CRE portion of viral RNA templates to the 3′ ends of positive- and negative-strand RNA templates to prime the initiation of RNA synthesis. These processes are supported within viral RNA replication complexes formed within cell-free translation-replication reactions (Goodfellow et al., 2003b; Lyons et al., 2001; Morasco et al., 2003; Murray and Barton, 2003; van Ooij et al., 2006).