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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: J Neurosci Res. 2009 Jun;87(8):1913–1921. doi: 10.1002/jnr.22012

Figure 3.

Figure 3

Progressive behavioral impairment indicative of a denervated striatum is evident post-intrastriatal LPS. (A) A graph of the average time spent on a rotarod shows, mice injected with LPS have a significant decrease in their duration on the rotarod beginning two weeks after LPS injection, and their performance decreases progressively with time (n=6 animals/group, where ** = p ≤ 0.001). (B) A graph of rotarod data from animals tested three months post-intrastriatal LPS or Saline injection, shows persistent behavioral impairment post-LPS. In addition, a subcutaneous injection of L-dopa/carbidopa (20/2mg/kg), prior to rotarod testing, significantly improves rotarod performance relative to baseline performance at 1 and 1.5 hours post-injection, where the effects of L-dopa/carbidopa wear off by 2.5 hours, and performance returns to the LPS damaged baseline levels (n=3/group, where ** = p ≤ 0.01 when comparing LPS vs. Saline). When comparing L-dopa/carbidopa effects in LPS mice vs. their twelve week impairment, p was = 0.029 and 0.044 for 1 and 1.5 hour time-points.