Table 1.
Demographic, anthropometric and clinical characteristics of the study cohort across tertile of Liver Fat Content (HFF %), adjusted for age, gender, race/ethnicity.
| Characteristic | Low Liver Fat Content (n=42) | Moderate Liver Fat Content (n=40) | High Liver Fat Content (n=36) | P-value Adjusted |
|---|---|---|---|---|
| Age (y) | 14.0 (2.9) | 15.3 (2.6) | 14.7 (2.7) | |
| Gender-no. (%) | ||||
| Male (n=37) | 7 (17%) | 12 (30%) | 18 (50%) | |
| Female (n=81) | 35 (83%) | 28 (70%) | 18 (50%) | |
| Race/Ethnicity-no. (%) | ||||
| White (n=49) | 7 (17%) | 21 (52%) | 21 (58%) | |
| African-American (n=39) | 24 (57%) | 10 (25%) | 5 (14%) | |
| Hispanic (n=30) | 11 (26%) | 9 (23%) | 10 (28%) | |
| Weight (Kg) | 101 (95.2, 106) | 101 (95.4, 106) | 102 (96.7, 108) | 0.91 |
| BMI (Kg/m2) | 36.4 (34.7, 38.1) | 37.1 (35.5, 38.7) | 38.3 (36.6, 39.9) | 0.32 |
| BMIz-score | 2.43 (2.35, 2.51) | 2.43 (2.36, 2.51) | 2.49 (2.42, 2.57) | 0.42 |
| Waist | 110 (106, 114) | 107 (104, 111) | 113 (109, 117)!! | 0.09 |
| DEXA | ||||
| %fat | 43.6 (41.2, 46.0) | 45.9 (43.7, 48.1) | 46.0 (43.6, 48.4) | 0.31 |
| Tissue Lipid Content | ||||
| Liver | ||||
| Hepatic Fat Fraction (HFF%)* | 0.7 (-1.6, 1.1) | 4.5 (2.8, 5.9) | 26.2 (15.2, 35.9) | - |
| Abdominal Region | ||||
| VAT (cm2) | 58.1 (49.3,67.0)‡ | 66.4 (58.0, 74.9)!! | 92.3 (83.2, 101) | <0.001 |
| SAT (cm2) | 582 (528, 637) | 573 (521, 625) | 610 (554, 665) | 0.61 |
| VAT/SAT | 0.10 (0.09, 0.12) | 0.12 (0.11, 0.13)!! | 0.16 (0.14, 0.17)‡ | <0.001 |
| DeepSubQ (cm2) | 201 (180, 223) | 208 (188, 229) | 220 (198, 241) | 0.47 |
| SupSubQ (cm2) | 156 (137, 175) | 153 (135, 171) | 145 (126, 164) | 0.74 |
| Deep/SupSubQ | 1.36 (1.19, 1.54)‡ | 1.47 (1.30, 1.64) | 1.75 (1.58, 1.91) | 0.007 |
Data are presented as means (95% C.I.).
*
Data are presented as median (IQR).
Data in bold indicate significance.
†
P<0.05 for difference between low and moderate
‡
P<0.05 for difference between low and high
!!
P<0.05 for difference between moderate and high