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. Author manuscript; available in PMC: 2009 Jun 8.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2494–2500. doi: 10.1158/1055-9965.EPI-05-0418

Conceptualization of polyp development under the “age shift” and “aggressive polyp” hypotheses. A. Polyp development in average-risk persons. B. Polyps (age shift) begin earlier, but the rate of transformation to malignancy is the same as for those without a family history. C. The age at onset is the same (aggressive polyp), but a higher proportion of polyps develop into invasive malignancies, and the sojourn time between onset and invasive disease is often shorter. , polyp onset times. , polyps that transform into invasive cancers.

Inline graphic — Conceptualization of polyp development under the “age shift” and “aggressive polyp” hypotheses. A. Polyp development in average-risk persons. B. Polyps (age shift) begin earlier, but the rate of transformation to malignancy is the same as for those without a family history. C. The age at onset is the same (aggressive polyp), but a higher proportion of polyps develop into invasive malignancies, and the sojourn time between onset and invasive disease is often shorter. , polyp onset times. , polyps that transform into invasive cancers.