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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Dev Biol. 2007 Aug 31;311(1):172–184. doi: 10.1016/j.ydbio.2007.08.044

Figure 7. Smad4 deficiency in NCCs causes reduced expression of Id genes and MT1-MMP important for extracellular matrix remodeling.

Figure 7

(A–D) RNA In situ hybridization on paraffin section reviewed a significant reduction of Id1 expression both in PA mesenchyme cells and in OFT mesenchyme cells at E10.5. C and D are higher magnification views of the rectangular regions in A and B. (E–H) RNA In situ hybridization on paraffin section reviewed a significant reduction of Id3 expression both in PA mesenchyme and OFT mesenchyme at E10.5. G and H are higher magnification views of the rectangular regions in E and F. (I–L) RNA In situ hybridization on paraffin section showed that MT1-MMP was down-regulated in PA mesenchyme and in OFT at E10.5 in the mutants compared to the controls. K and L are higher magnification views of the rectangular regions in I and J. EN: endothelia; MYO: myocardium. Triangles point to the splanchnic mesoderm within the SHF.