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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Mol Biochem Parasitol. 2009 Apr 5;166(2):142–152. doi: 10.1016/j.molbiopara.2009.03.009

Figure 4. Growth of WT, ftl− and ftl−/+FTL L. major in low concentrations of glycine and serine.

Figure 4

A. Parasites were adapted and grown in semidefined RPMI media as described in the methods. Growth is shown relative to that of WT in complete RPMI media (= 100%). Amino acid levels were altered as follows: 5-fold reduced levels of glycine (Gly 5-fold lower), or serine at 15 or 30-fold lower levels, (Ser 5-fold lower or Ser 30-fold lower, respectively). White bars, WT; black bars, ftl−; and gray bars, ftl−/+FTL. The data are the mean of three independent experiments, with the standard deviation shown. B. Pathway for FTL and DHCH-dependent interconversion of serine and glycine.