Table 3.

Association of anti–PAD-4 antibodies with the heterozygous diplotype in the 111 white patients in the ESCAPE RA cohort^*

Diplotype	No. of patients	OR (95% CI)
1 and 1	33	1
1 and 2	53	4.02 (1.43–11.3)†
2 and 2	19	2.63 (0.726–9.49)

^*Patients were grouped according to the presence of 1 or 2 alleles of either haplotype 1 (the nonsusceptibility haplotype) or haplotype 2 (the susceptibility haplotype). Odds ratios (ORs) and 95% confidence intervals (95% CIs) for the presence of anti–PAD-4 autoantibodies, compared with patients who were homozygous for haplotype 1, were calculated. A similar analysis evaluating associations between diplotypes and anti–cyclic citrullinated peptide antibodies did not yield statistically significant results. See Table 1 for other definitions.

^†P = 0.009.